Meet your simple,
skincare routine


Glow from the inside out!

The perfect one-two combo for healthy, radiant skin

M4 Face Creamrx icon

M4 Face Cream

149.97 (3 month supply)

Our fragrance-free, custom-blended estriol moisturizer which works to replenish estrogen, increase collagen production, and address signs of aging.

How to use:

Use M4 in the morning or at night after serums, before moisturizers.

Tretinoin Face Creamrx icon

Tretinoin Face Cream

$30 off with purchase of m4

$60.0090.00 (3 month supply)

Our fragrance-free topical treatment for acne, fine lines, hyperpigmentation, and discoloration.

How to use:

Use Tretinoin after moisturizer as part of your night time routine.

M4 is clinically proven safe and effective

In an independent clinical study, statistically significant improvements seen in M4 Cream compared to placebo in just 12 weeks include:

arrow up88%
improvement in elasticity
arrow up68%
improvement in skin health
arrow up70%
improvement in hydration
arrow up57%
improvement in skin texture

M4 can be used with or without MHT because it does not impact blood estrogen levels. No changes in serum estriol and estradiol levels.

Read the full clinical study

Science-backed ingredients



Increases collagen production, retains and restores skin moisture, increases skin firmness, increases skin elasticity and decreases pore size.


Estriol, aloe barbadensis leaf juice , C 12 - 14 isoparaffin, caprylic/capric triglyceride, deionized water, laureth-7, phenoxyethanol, polyacrylamide, tocopheryl acetate, and triethylene glycol.

woman applying cream

Did you know?

Up to 30% of dermal collagen is lost during the first 5 years of menopause, and decreases by an extra 2.1% every year after.

Reverse the effects of estrogen deficiency

Perimenopause, menopause, and aging mean estrogen deficiency. Estrogen deficiency means loss of collagen, decreased elasticity and loss of moisture. Our skincare was specially formulated to

  • Plump and firm skin
  • Shrink the appearance of pores
  • Alleviate dryness and dullness
  • Restore elasticity for a rejuvenated complexion
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What Alloy customers are saying

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I love the M4 Face cream as part of my daily skincare routine. I am an Advanced Practice Esthetician and specialize in peri-post menopausal skin. I have recommended it to many of my clients. It’s such a great addition to what I offer.

Cindy on Trustpilot
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The online app is excellent- user friendly, clear and efficient. I received responses from the doctor within an hour of me sending messages. As healthcare provider myself, I was so impressed with the entire experience. I purchased the M4 face cream- saw results within a week. Again. so impressed. And grateful that there is a site out there to help us navigate the waters of peri-menopause/menopause in a way that has been hard for me to find in standard medical practices. Thank you SO much.

Erin on Trustpilot
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“I really love the face cream a lot! I have used an estrogen facial moisturizer from other providers before but this one from myalloy is the best. They all have the estrodial but myalloy has a beautiful formulation . The texture is excellent with absolutely no weird sticky or absorbed beautifully and wears under makeup and sunscreen very well. It 100 helps with maintaining moisture, suppleness and plumpness in the skin. My skin barrier is healthy and with that comes a glow to the skin. It is a very elegant formulation that is affordable. Thank you so much!”

Kim on Trustpilot
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“The M4 cream is fantastic. It was delivered straight to my door and I am noticing great benefits to my face and neck. It’s so hard to find providers who are up to date on menopause care. Thanks Alloy!”

Alyssa on Trustpilot
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“I am amazed at the difference in my face and neck from just two weeks of using M4. My fine lines have almost disappeared and my skin is definitely more supple. The product layers perfectly with my serums and tretinoin and I love that it’s fragrance free.”

Michelle on Trustpilot
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“The M4 cream is fragrance-free and has enhanced my facial dryness and dullness almost immediately. My Mom always says, "your face looks brighter and healthier."

Kim on Trustpilot
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“The Estriol face cream is magic. Skin looks plumper. Less dry. Also love the ease and efficiency of obtaining care from the staff and doctors using online questionnaires and prescriptions.”

KimTX on Trustpilot

How it works


Take our skin assessment

It should only take about a minute!


Select your treatments

Choose the treatments you'd like to request from the doctor.


Doctor review

A doctor will review and write your prescriptions.


Treatments delivered to your door

We'll ship everything right to you!

Related Research

Gehring, W. “Nicotinic Acid/Niacinamide and the Skin.” Journal of Cosmetic Dermatology, vol. 3, no. 2, Apr. 2004, pp. 88–93,

Griffiths, Christopher E. M. “Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation.” Archives of Dermatology, vol. 131, no. 9, 1 Sept. 1995, p. 1037,

Hajheydari, Z., et al. “Effect of Aloe Vera Topical Gel Combined with Tretinoin in Treatment of Mild and Moderate Acne Vulgaris: A Randomized, Double-Blind, Prospective Trial.” Journal of Dermatological Treatment, 2014,

Lephart ED, Naftolin F. Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatol Ther (Heidelb). 2021 Feb;11(1):53-69. doi: 10.1007/s13555-020-00468-7. Epub 2020 Nov 26. PMID: 33242128; PMCID: PMC7859014.

Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761.

Sitohang, Irma Bernadette S., et al. “Topical Tretinoin for Treating Photoaging: A Systematic Review of Randomized Controlled Trials.” International Journal of Women's Dermatology, vol. 8, no. 1, Mar. 2022, p. e003,