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most populardaily pill

Estradiol Pill

$39.99 per month
(Sold in a 3-month supply)

So long, symptoms! The estradiol pill is proven to provide effective, fast relief from your menopause symptoms. The estradiol we offer is FDA-approved, bioidentical & plant-based.

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No uterus tax here!

Have a uterus? Prescribed systemic estrogen? We'll include the progesterone you need to protect your uterine lining at no extra cost.

Learn more about the Estradiol Pill

What is it: The estradiol pill is FDA-approved, plant-based, bioidentical hormone treatment for the alleviation of the symptoms of menopause.

Who is it for: The FDA has approved estrogen for the treatment of vasomotor symptoms, prevention of osteoporosis, treatment of the Genitourinary Syndrome of Menopause and treatment of premature menopause (menopause before age 45). Estrogen is the only medication that has been proven to relieve menopausal hot flashes, night sweats and prevent osteoporosis.

The estradiol pill, or oral bioidentical estradiol, can be used safely in most women. The estradiol pill can be taken by healthy women who do not smoke, have well controlled blood pressure, no history of heart disease or stroke, liver disease, or do not have a history of blood clots or genetic mutations that increase your risk for blood clotting. 

If you are unsure which type is right for you, your menopause trained doctor will review your medical and family history and  can help you decide. The decision to use one type over the other can be based on cost, ease of use and personal preference. 

Women who have undiagnosed vaginal bleeding, active liver disease, a personal history of heart attack or stroke, or a history of estrogen dependent cancers, such as breast or uterine cancer, may not be candidates for estrogen therapy. Please note that a family history of any of these conditions is not a contraindication to menopausal hormone therapy.

What am I getting: 3-month supply of oral estradiol pills in tablet form. If you have a uterus (and don't have a progestin IUD like Mirena or Liletta), you'll also receive oral progesterone.

How to get it: Prescription required. You'll be assigned a menopause-trained doctor who will review your symptoms and medical history. You'll receive personalized treatment recommendations and together will come up with a plan. We'll ship everything to your door and you'll be able to message your doctor any time for free for as long as your prescription is active.

Simple daily pill
Take one estradiol pill daily in the morning or at night. Pro-tip: If you're taking progesterone with it, we recommend taking it at nighttime since it can have a sedative effect.
Multi-symptom relief
Estradiol is the primary estrogen produced by the body and the most potent form of estrogen. Hormone therapy replenishes your body’s estrogen with just a small dose and is FDA-approved to relieve menopause symptoms.
See results in as little as 2 weeks
While results timelines may vary, 95% of Alloy customers taking MHT feel symptom relief in 2 weeks or less.

Not sure what you need?

That's what our intake is for! After you complete our medical questionnaire, a menopause-trained doctor will review your symptoms and medical history and answer your questions to help you find the best solution(s) for you.

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Did you know?

95% of Alloy customers taking MHT feel symptom relief in 2 weeks or less

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What is Estradiol?

Estradiol is the primary estrogen produced by the body and is considered to be the most powerful. The estradiol in Alloy-prescribed products is molecularly identical to the estradiol your body produces naturally.

Our bodies need estrogen for the normal function of multiple organ systems, including our brains, bones, and hearts. As we go through menopause, our estrogen levels dramatically decrease, and this is what causes symptoms. Replenishing your body's natural estrogen in small doses can help you feel your best and stay healthy for longer.

How it works

1.

Tell us about yourself

Fill out a quick medical intake form.

2.

Work with a menopause trained doctor

Create a treatment plan for your symptoms.

3.

Get relief delivered

Prescription medication delivered to your door.

Frequently asked questions

  • How do I know if the estradiol pill is right for me?+
    Your menopause-trained doctor will review your symptoms and medical history and help determine the best treatment plan for you. The estradiol pill can be taken by healthy women who do not smoke, have normal blood pressure, do not have unusual vaginal bleeding, and have no history of heart disease, liver disease, or blood clots. If you have a history of endometrial or breast cancer, are a BRCA1/2 carrier, or have undiagnosed vaginal bleeding, coronary heart disease, blood clots, or stroke, oral estrogen use may not be recommended for you.
  • Can I take this pill with other forms of hormone treatment?+
    The estradiol pill can safely be used alongside local hormonal treatments, like vaginal estradiol and M4. If you have an intact uterus, progesterone is required and will be sent to you with your estrogen. Please consult with your doctor about any other hormone treatments you are currently taking before starting treatment with Alloy.
  • What is Menopausal Hormone Therapy and is it safe for me?+
    When you go through menopause, your body stops making estrogen, which causes symptoms like hot flashes, sleeplessness, and mood swings, and leads to conditions like osteoporosis. Menopausal Hormone Therapy (MHT), also known as Hormone Replacement Therapy (HRT), is a treatment that replenishes the estrogen your body stops making, but still needs. At Alloy, all of the MHT we prescribe is bioidentical, which means it’s chemically identical to what your body was making before. For the vast majority of women, this treatment is very effective and completely safe. Your menopause-trained doctor will use your medical intake to determine the best treatment for you, and if you have any questions, you can always reach out to ask!
  • What is progesterone and why is it prescribed?+
    Progesterone regulates the menstrual cycle and helps keep the uterine lining thin. For people with intact uteruses taking supplemental estrogen in menopause, progesterone is prescribed to protect the uterine lining.
  • Is the estradiol pill eligible for HSA or FSA reimbursement?+
    Yes! Your consult and the medication are both eligible. The consult is considered a telehealth or telemedicine visit and is generally reimbursable. Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Your invoice is available to download and include when you submit to your plan for reimbursement. If you require more information, please contact us at support@myalloy.com and we will assist you. Note: The IRS defines which medical expenses are eligible under an HSA or FSA and the products carried on Alloy are in compliance with these requirements. However, these plans can vary and some may not allow all eligible HSA or FSA expenses. It's important to always check with your benefits administrator to determine which expenses are eligible before you shop.
  • Where is Alloy available?+
    At this time, Alloy is available in all 50 U.S. states, plus Washington, D.C. If you live outside the U.S., you are still welcome in the Alloy community! You can sign up for our newsletter, follow us on social media @myalloy, access our blog, and enjoy our webinars as well as other free resources, regardless of where you live.

What Alloy customers are saying:

The Alloy Promise

Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.


All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.


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