Woman sitting in front of a window applying M4 lotion to her face.
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Best for addressing signs of aging


A fragrance-free restorative estriol face cream to address signs of aging like decreased collagen production, increased wrinkles, and dryness.

$149.97 ($49.99 / month)

  • prescription bottle icon

    Prescription included

  • free shipping icon

    Free shipping, cancel anytime

  • unlimited messaging icon

    Unlimited messaging with a menopause-trained doctor

Did you know?

Up to 30%

of dermal collagen is lost during the first 5 years of menopause and decreases by an additional 2.1% every year after.
Asian woman with red nail polish, hair wrapped in towel applying dots of cream to her face. AW450

Learn more about M4

What is it: M4 is a fragrance-free prescription estrogen-based face cream created specifically for perimenopausal and menopausal women. Active ingredients include topical estriol (addresses signs of aging), glycerin (an excellent humectant), oleic acid (moisturizes, anti-inflammatory, and rich in antioxidants), and vitamin E (softens skin, provides UV protection, and moisturizes).

Full list of ingredients: estriol, C12 - 15 alkyl benzoate, caprylic/capric triglycerides, cetyl alcohol, ethylhexylglycerin, glycerin USP, glyceryl stearate, hydroxyethyl acrylate/sodium acryloyldimethyl, taurate copolymer, oleic acid, olive oil, PEG-100 stearate, phenoxyethanol, polymethylsiloxane, purified water, stearic acid, trolamine NF, and vitamin E acetate.

Who is it for: For any woman–really, any woman–looking to reverse the effects of estrogen-deficiency in the skin due to menopause, perimenopause, or just aging (loss of collagen, decreased elasticity and moisture, and appearance of wrinkles).

What am I getting: One tube of M4 contains a 3-month supply (1.52 oz /45ml).