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treats vaginal symptoms

Estradiol Vaginal Cream

$39.99 per month
(Sold in a 3-month supply)

$13 off per month with purchase of O-mazing

Localized, topical estradiol cream to provide effective relief for vaginal dryness, itching, burning and the prevention of frequent UTIs.

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Get $13 off per month with O-mazing

Save when you purchase Estradiol Vaginal Cream and O-mazing together. Learn more

Learn more about the Estradiol Vaginal Cream

What is it: Estradiol cream is an FDA-approved, plant-based, bio-identical, local hormone treatment for the alleviation of genitourinary symptoms (vaginal dryness, itching, burning, painful sex, frequent UTIs) due to menopause.

Who is it for: Vaginal estradiol cream is recommended for any woman experiencing vaginal symptoms like dryness, burning, itching, frequent UTIs and painful sex.

What am I getting: 3-month supply of estradiol cream (0.01%).

How to get it: Prescription required. A menopause-trained doctor will review your medical history to determine if this is the right treatment for you.

A simple, low-dose cream
Estradiol vaginal cream is a very low-dose topical estradiol cream. The small amount of estrogen in the vaginal cream is absorbed locally, and treats the symptoms of the Genitourinary Syndrome of Menopause (vaginal dryness, itching, painful sex, frequent UTIs, etc).
Multi-symptom relief
Vaginal estradiol is FDA-approved to treat vaginal dryness, pain, painful sex, itching and frequent UTIs by rejuvenating the tissue in and around the vagina, increasing moisture and improving elasticity. It also restores the vaginal pH to an optimal level.
See Results in as Little as 12 Weeks!
While results timelines vary, most people see significant improvements in their vaginal health within three months.

O-mazing + Estradiol Vaginal Cream = the perfect combo for improved sexual health

Perimenopause, menopause, and aging mean the possibility of issues like decreased desire, painful sex, dryness, and bladder issues. Our sexual and vaginal health treatments are specially formulated to:

  • Relieve dryness, itching, and burning
  • Alleviate painful sex
  • Decrease frequent UTIs
  • Treat bladder issues
  • Stimulate natural lubrication
  • Enhance arousal and satisfaction

We love 'em on their own, but they're better together. Get $30 off when you buy O-mazing and Estradiol Vaginal Cream together.

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Did you know?

80% of women will see improvement in vaginal symptoms within 4-12 weeks of starting treatment

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What is Estradiol?

Estradiol is the primary estrogen produced by the body and is considered to be the most powerful. The estradiol in Alloy-prescribed products is molecularly identical to the estradiol your body produces naturally.

Our bodies need estrogen for the normal function of multiple organ systems, including our brains, bones, and hearts. As we go through menopause, our estrogen levels dramatically decrease, and this is what causes symptoms. Replenishing your body's natural estrogen in small doses can help you feel your best and stay healthy for longer.

How it works

1.

Take our assessment

It should only take about a minute!

2.

Select your treatments

Choose the treatments you'd like to request from the doctor.

3.

Doctor review

A doctor will review and write your prescriptions.

4.

Treatments delivered to your door

We'll ship everything right to you!

Frequently asked questions

  • How do I know if Estradiol Vaginal Cream is right for me?+
    Your menopause-trained doctor will review your symptoms and medical history and help determine the best treatment plan for you. If you are experiencing vaginal symptoms of menopause, including itching, burning, dryness, painful sex, and/or frequent UTIs, you are a candidate for topical vaginal estradiol. It is safe for everyone to use and is very effective.
  • Can I use Estradiol vaginal cream with other forms of hormone treatment?+
    Estradiol vaginal cream can be used alongside any other treatments prescribed by Alloy, including Menopausal Hormone Therapy and M4.
  • What is Estradiol vaginal cream and why is it prescribed?+
    Estradiol vaginal cream is localized (non-systemic), topical estradiol cream. It is prescribed to provide effective relief from genitourinary syndrome of menopause, including symptoms like vaginal dryness, itching, burning, and for the prevention of frequent UTIs. It is very effective and safe to use.
  • Do I need progesterone?+
    If you are using Estradiol vaginal cream and are not taking systemic MHT, you do not need progesterone. But, if you’re already taking it, it is totally fine to use them together!
  • Where is Alloy available?+
    At this time, Alloy is available in all 50 U.S. states, plus Washington, D.C. If you live outside the U.S., you are still welcome in the Alloy community! You can sign up for our newsletter, follow us on social media @myalloy, access our blog, and enjoy our webinars as well as other free resources, regardless of where you live.

What Alloy customers are saying

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“I was amazed at how informed and prompt the doctor was in responding to my questions and helping me! I am a doctor myself and very very informed about many things to do with my health but I am an oncologist. I have learned so much from the doctor and Alloy and the YouTube channel! So many brilliant capable women standing up and saying no more this is not OK and we’re gonna fix this now. I am so thrilled to be part of Alloy! I have referred every woman I know to the site.”

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Lisa on Trustpilot
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My experience has been excellent. They responded quickly, listened to my symptoms and responded with a protocol that’s easy to follow. I’m feeling 100 percent better. Thank you so very much.

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Ketteridge on Trustpilot
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Thankful for Alloy and their doctors that make women’s health a priority! I love that I don’t have to jump through hoops or over-explain my needs in order to get the menopausal healthcare that I need in order to live a vibrant life. Thank you!

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Regina on Trustpilot
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“I love this was a hassle free process, and I felt I was actually listened to and taken seriously, something I feel can be sorely lacking in the medical world when it comes to women. Women know their bodies, and it shouldn’t be a struggle to get the treatment that works best for you. We’re all different, and the key is finding what works for us individually. Thank you, Alloy. My quality of life during perimenopause is so much better now!”

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Stephanie on Trustpilot
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“This company is great. I have access to a doctor who prescribed hormones when no other doctor would. I am happy and relieved that Alloy provides top notch service in their doctors and customer service.”

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Cathy on Trustpilot

The Alloy Promise

Alloy believes that every woman deserves accurate, up-to-date information and the agency to make her own decisions about her health based on facts, not fear.


All of our board-certified physicians follow ACOG and The Menopause Society guidelines and prescribe only FDA-approved, generic medications for the treatment of menopausal symptoms. The safety of our products is our top priority.


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